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What is Ambien?
Buy Ambien Online – Zolpidem sells under the brand name Ambien. It is a sedative-hypnotic to help induce sleep. FDA recommends that people should buy Ambien online for use only after trying proper counseling and behavioral changes. Ambien is a medication that decreases sleep onset time by 15 minutes and helps stay asleep at larger doses. It is an oral medication available as generic pills as well as conventional brand name tablets.
Ambien is a non-benzodiazepine medication acting as both a hypnotic and a sedative. It is a type-A agonist of the GABA (gamma amino-butyric acid) receptor belonging to the group of an imidazopyridine, increasing the effects of GABA in the central nervous system by attaching to GABA-A receptors similarly like benzodiazepines.
The typical half-life of Ambien ranges from two to three hours. It means that half of an Ambien pill takes about two to three hours to clear out from your body. Patients with liver problems have increased Ambien half-life.
Zolpidem, the active ingredient of Ambien, got approval for medical use in the year 1992 in the United States. You can buy Ambien online as a generic medication also as its generic version came to the market in 2007.
The DEA (Drug Enforcement Administration) puts Ambien under the schedule-IV of the controlled substance act 1970. Ambien is one of the most widely prescribed sleep-inducing medications in the United States, with more than 10 million prescriptions every year.
Uses of Ambien
Buy Ambien online for short-term treatment of sleep problems or insomnia at the minimum beneficial dose. Its treatment session typically ranges from two to six weeks. Ambien is useful both in improving sleep onset and sleep duration.
The ACP (American College of Physicians) indicates that Ambien should be a second-line treatment for insomnia only after using non-pharmacological treatment options such as cognitive-behavioral therapy. It is due to a 2012 review showing the effectiveness of Ambien is nearly as much because of the psychological effects as to the medicine itself.
Mechanism of Action
Ambien pills contain zolpidem as an active ingredient, which is a ligand of high-affinity favorable modulator locations of GABA-A receptors. It enhances GABAergic inhibition of neurotransmitter activity in the central nervous system. It selectively attaches to alpha-1 subunits of the pentameric ion channel. According to this, it also has high hypnotic properties and weak myorelaxant, anxiolytic, and anticonvulsant properties.
Unlike diazepam, zolpidem can attach to binary alpha-beta GABA receptor, where it also binds to the alpha-1 to alpha-1 subunit interface. It has about 10 times lower affinity for the alpha-2 and alpha-3 subunits than for alpha-1, and almost no affinity for alpha-5 subunit-containing receptors. Zolpidem can increase slow-wave sleep, yet cause no effect on stage 2 sleep.
The most frequently occurring adverse effects of short-term Ambien use include drowsiness (reported by 2% of people in clinical trials), headache (7%), diarrhea (1%), and dizziness (1%).
The common effects of long-term use include dizziness (5%), drowsiness (8%), sinusitis (4%), allergy (4%), diarrhea (3%), back pain (3%), dry mouth (3%), feeling drugged (3%), sore throat (3%), lethargy (3%), constipation (2%), abdominal pain (2%), lightheadedness (2%), heart palpitations (2%), rash (2%), amnesia (1%), abnormal dreams (1%), depression (1%), chest pain (1%), sleep disorder (1%), and flu-like symptoms (1%).
Ambien also increases risks of falls and bone fracture, depression, suppressed respiration, poor driving, and associated risk of death.
Upper and lower respiratory tract infections are also common with the use of Ambien.
Ambien can interact with several drugs to produce unwanted effects. You should buy Ambien online only after telling your prescribing doctor about all the prescription and non-prescription medicines that you take.
Individuals should not consume alcohol or alcoholic beverages while taking Ambien as it increases respiratory depression.
Do not take prescribed or recreational opioids as it increases the risk of dependence on one or both of the medicines, central nervous system depression, and death.
People may have worse next day sedation if they take Ambien concurrently with other sedatives, antipsychotics, antidepressant agents, anxiolytics, antihistamines, and antiepileptic drugs.
There are reports of visual hallucinations associated with the concomitant use of Ambien and antidepressants.
Cytochrome P450 inhibitors like CYP3A4 and CYP1A2 inhibitors, ciprofloxacin, and fluvoxamine can increase the effects of Ambien.
Cytochrome P450 activators such as St. John’s Wort decrease the activity of Ambien.
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